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(2019) Role of GPX4 in ferroptosis and its pharmacological implication, Free Radic

radicals and toxins, helping to keep our system clean

Activation of HIF-1 signaling by PHD2 deletion under normoxia enhanced glutamine uptake and upregulated GLS1 expression leading to enhanced glutaminolysis and increases in cellular GSH levels and in GSH/GSSG, which correlated with upregulation of antioxidant genes ( SOD1 , SOD2 , catalase , GPx1 , and GR ) and reduction in cellular and mitochondrial ROS production, indicatives of reductive stress (96)