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Genetic studies have implicated the critical functions of the key components of the UFMylation pathway, including UBA5, UFC1, and UFL1, in regulating GBM cell survival, 11 resistance to chemotherapy 11 and radiotherapy, 12 and immune evasion, 13,14 suggesting a pro-oncogenic role of UFMylation in GBM

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This process was repeated daily for 10 days with new CD-1CSDSMWDS pairings to prevent habituation