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NO can be produced by isoforms of NO synthases (NOS), including the neuronal (nNOS), inducible (iNOS), and endothelial isoforms (eNOS), and via the non-classical nitrate-nitrite-NO pathway

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doi:10.1016/j.mjafi.2014.12.022

Detoxification & Environmental Medicine This article examines how commonly used pain medicationsincluding NSAIDs, acetaminophen (Tylenol), corticosteroids, and opioidscan deplete nutrients, strain detoxification pathways, disrupt hormones, impair tissue repair, and ultimately interfere with long-term healing and chronic pain resolution