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The enzyme cystathionine--synthase (CBS) that catalyzes the first step in the transsulfuration pathway is highly expressed in liver cells but not highly expressed in peripheral cells, so it is not surprising that the liver is the major producer of GSH, much of which is exported to the plasma and enzymatically broken down to cysteinylglycine and cyst(e)ine that is subsequently taken up by other cells for GSH synthesis

Prevalence of the metabolic syndrome among Omani adults

128 To facilitate mitochondrial DNA repair, all the proteins necessary for this process must be imported from the cytoplasm because mtDNA does not encode them

Key Strengths: Key Weaknesses: Ideal Patient Profile: Patients who refuse or can't tolerate injections

Chiang, C

J Clin Invest 127:280292