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Because it looks so much like glutamate, L-theanine can interact directly with the brain's complex receptor networks, binding to sites that would normally trigger neurological excitation

Environmental Microbiology

The immune system can keep activating long after the pathogen is gone, holding the body in a low-grade defensive state that continuously costs energy

Activated microglia drive demyelination via CSF1R signaling

This not only saves excipient costs but also simplifies formulations and reduces the difficulty of quality control

Similarly, in the SDT-f-DKD rat model, elevated plasma long-chain acylcarnitines are associated with mitochondrial fragmentation in renal tubules, suggesting their direct involvement in renal injury [100]