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The clearance (L/hr) of APAP increased from 2.02 L/hr at 1 month of age to 4.09 L/hr at 1 year of age to 14.27 L/hr at 16 years of age (based on our own analyses on the published mean values with a Spearman correlation, there is a significant correlation between age and APAP clearance, p G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A Exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure

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Lewerenz J, Sato H, Albrecht P, Henke N, Noack R, Methner A, Maher P

Matsuo Y, Nakamura S, Adachi T, Tsubota T

PLoS One 18 , e0288820 (2023)

This imbalance between methionine supply and demand leads to a decrease of approximately 40%-60% in S-adenosylmethionine (SAM) levels within T cells (157)