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Concerns were first raised for ADE in patients with SARS when seroconversion and neutralizing antibody responses were found to correlate with clinical severity and mortality 46

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[DOI] [PubMed] [Google Scholar] Lin QLi SJin HCai HZhu XYang YWu JQi CShao XLi J, et al

and is currently principal investigator on a clinical trial of intensive urate-lowering therapy (funded by the Health Research Council of New Zealand)

To summarize, although very potent IRAP inhibitors have been discovered after systematic alterations starting from Ang IV none of the compounds are expected to reach the brain, at least not after oral administration