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Hepatic Gclc KO has been shown to increase levels of serum ALT and AST, suggesting increased liver injury, whereas Chac1 overexpression leads to decreased levels of ALT and AST, indicating a protective effect

Along with the ability to deplete CD38 + malignant plasma cell populations which has led to their widespread therapeutic use, anti-CD38 antibodies are involved in the polarization and release of microvesicles characterized by the expression of multiple adenosine-producing molecules

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Biochemistry 38 , 66996705 (1999)

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(2020) 12(12):e12368