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One of the primary pathways is the PI-3 kinase pathway, which leads to the activation of protein kinase B (AKT)

In NCT01835041 and NCT03504423, CPI-613 was combined with chemotherapy for the treatment of metastatic PDAC, yielding a good response rate [316]

doi:10.1519/JSC.0b013e31817d48d9

2dg and Extended Data Fig

The lactic acid bacteria group consists of vast strains of Gram-positive, facultative anaerobic rod-shaped bacteria (including Lactobacillus , Lactococcus , and Enterococcus ), which secrete lactic acid as byproducts in carbohydrate metabolism [92, 163, 223, 287]