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The incubation of vonifimod with human hepatocytes resulted in the formation of nine metabolites, including hydroxy-vonifimod (M1 and M2), inactive carboxylic acids (M3 M6), active vonifimod-phosphate (M7), and M3 glucuronides (M3-G1 and M3-G2)

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Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock