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But there are several obstacles to the development of this senolytic approach such as the long-term effect of CAR-T cells therapy with possible aspecific toxicity in different organs 56 , the cost and the difficulty during process development 57 or the selection of non-exhausted T cells to generate efficient therapy 58,59

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Supplementary material The Supplementary Material for this article can be found online at: References 1 Global tuberculosis report 2024

then, the active receptors can be recycled to the surface of the cytomembrane [90,95]