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20 NRF2 was first identified in 1994, 21 and by 1996, 22 it had been discovered that under oxidative stress conditions, it could activate the expression of antioxidative enzyme genes, including NQO1, GPX4, TXN, and PRDX1

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A proximal AP-1 element (263 to 269) was found to be critical in mediating the effect of oxidative stress-induced increase in human GCLC transcription [98103]

10.1038/nature08933 83 JeongH.ChoiD.OhY.HeoJ.HongJ

YL: Investigation, Writing original draft

from Greek that means being alone with yourself) is a hypernym embracing the extended group of polyaetiological pathologies manifested by deviant social interactions, impaired language skills, and restrictive behaviours