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In 1990, Broelsch et al., reported the first 20 series of LDLT in the USA [55]

However, heat shock stress during cryopreservation can compromise oocyte viability

Along with widely accepted conventional mechanism of desensitization, studies of various GPCRs including dopamine D2-like receptors (D 2 R, D 3 R, D 4 R) have suggested the existence of another desensitization mechanism

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In conclusion, we found that metformin may alleviate the pathological progression of OA primarily by activating Nrf2 signaling pathway, thereby confirming the promising potential of metformin as a treatment paradigm for OA