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The recovery of all plasma samples ranged between 96.23% and 108.77%, whereas that of the brain tissue sample was between 96.57% and 106.51%

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Although analyzing DNA methylation in blood as a surrogate for brain has its limitations with regard to underrepresentation of the alterations that take place in the disease-affected tissue, it has a potential use in the identification of biomarkers that could help diagnosis and disease monitoring