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Due to the already sensitive nature of dopaminergic neurons to redox imbalance and ROS generation, the additional reduction of an antioxidant like GSH causes neuron loss (Smeyne and Smeyne, 2013)

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Avoid repeated freeze-thaw cycles and minimise exposure to air to prevent oxidation to the disulfide form (GSSG)

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They possess multiple cell-surface receptors which react to various stimuli and, after activation, release numerous mediators including histamine, heparin, cytokines, prostaglandins, leukotrienes and proteases (153)

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