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*Correspondence: Dan Li, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Originally derived from research into TWIK-related K+ channel 1 (TREK-1) modulation, PE-22-28 represents a novel therapeutic approach to mood disorders and cognitive enhancement through selective potassium channel inhibition

This cytokine induces its own expression in activated HSCs, thereby creating a self-perpetuating cycle of events, referred to as an autocrine loop

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After in vitro ubiquitylation/deubiquitylation of wild-type or C224R OTUD5 with TRIP12/UBR5, OTUD5 was purified using anti-HA immunoprecipitation