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Mild headaches or discomfort can occur rarely, but it's generally well-tolerated

10.1186/1750-1172-1-16 Carelli V, Carbonelli M, de Coo IF, et al.: International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy

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Dihydroorotate dehydrogenase (DHODH), a mitochondrial enzyme involved in ferroptosis regulation [13], presents an alternative pathway for inducing ferroptotic cell death, particularly in GPX4-low expressing glioblastoma cells

these pruritus responders also had mean reductions in bile acids and improvements in sleep parameters and PedsQL scores compared with baseline (Table 1)