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This study aims to demonstrate the causal effect between VEGF and IS using Mendelian randomization (MR)

Longer-term continuous use (6+ months) has less established safety data, though no significant concerns have emerged

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J Intern Med 273(2):114127 Takahashi T et al (2001) A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

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Chickenpox was once very common among children, but its incidence has fallen dramatically in the United States since VZV vaccination was introduced as a childhood immunization in 1995