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On the other hand, GO analysis of the 1,281 genes upregulated on all mutant diets showed enrichment for molecular functions related to monooxygenase, oxidoreductase, UDP-glucosyltransferase, and iron ion binding activities (Fig

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TET1, TET2, and TET3 can subsequently oxidize 5-hmC into 5-formylcytosine and 5-carboxylcytosine ( via the base excision repair (BER) pathway ( Alcohol induces DNA hypomethylation in the liver By altering the activity and expression of enzymes involved in one-carbon metabolism, such as methionine synthase, methionine adenosyltransferase, and betaine-homocysteine methyltransferase, alcohol consumption decreases the methylation index in the liver ( Ethanol also reduces dietary folate absorption by altering the binding and transport kinetics of the folate transport system and reducing the expression of folate transporters in the intestines and kidneys (26)