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Targeting and therapeutic peptide-based strategies for polycystic kidney disease

Sodium hydroxide and/or hydrochloric acid is added to adjust pH (range 6.0 - 7.5)

The accelerated approval of tofersen for SOD1-ALS marks a pivotal advance in precision medicine but also highlights a critical gap: effective strategies for the vast majority of patients without such targetable mutations (8, 9)

Discussions In this retrospective cohort of critically ill patients with sepsis associated delirium, ICU thiamine supplementation was consistently associated with a significantly lower risk of 30-day mortality