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However, liver mitochondria from mice lacking ANT1 and ANT2 can still undergo Ca 2 + -induced swelling and MPT, although at a higher threshold, which has been interpreted as evidence against a role for ANT in MPT (Kokoszka et al., 2004)

Interestingly, this increase in H 2 O 2 production was diminished by over 50% when NADH oxidation and mitochondrial respiration were enhanced by subsequent addition of ADP or the respiratory uncoupler carbonyl cyanide-p-trifluoromethoxy-phenylhydrazone (FCCP)

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Studies show that even sub-maximal exercise for 30 minutes is enough to elevate oxidative stress, and high levels of ROS are known to be involved in several pathophysiological implications

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