Bioavailability of testosterone micronized orally is low and highly variable, with estimates putting it at 3.56 +/-2.45%, with testosterone undecanoate having higher bioavailability at 6.83 +/- 3.32%, and methyltestosterone having the highest bioavailability at around 70%.15,16 It should be noted that this superior bioavailability of methyltestosterone due to avoiding first pass metabolism is associated with increased hepatotoxicity, whereas regular oral micronized testosterone and testosterone undecanoate salt, though they are significantly less bioavailable via the oral route, are not anticipated to present significant hepatotoxicity

Tsvetkov P and his team compared mice lacking the ATP7B gene (a mouse model for Wilsons disease) with normal mice, and observed typical indicators of cuproptosis in liver cells of mice lacking the ATP7B gene, including lipoylated protein oligomerization, depletion of iron-sulfur proteins, and increased abundance of HSP70 ( Both ATP7A and ATP7B are highly relevant to diabetes
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Antioxidant treatment of patients with asthenozoospermia or moderate oligoasthenozoospermia with high-dose vitamin C and vitamin E: a randomized, placebo-controlled, double-blind study
Zafar et al., 2024a)