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The reason is simple: Metformin can block or diminish many of the fundamental factors that accelerate aging

LIAS, a member of the biotin and lipoic acid synthase family, is predominantly localized in mitochondria

10.1016/j.clnesp.2021.04.005 2 AhmadiA.ValenciaA

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The proteomic approach revealed the up-regulation of MAP 2 (P20357) and the exclusive expression of MAP 1A and 6 (Q9QYR6 and Q7TSJ2, respectively) in the 10 mg/L group compared with the control group