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in 1993.27 APC resistance was subsequently shown to be a risk factor for venous thrombosis.28 More than 90% of patients with APC resistance have been shown to have a single point mutation in factor V gene.29 This mutation hinders the degradation of factor V normally occurring through protein C

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Therefore, highly perfused organs, with a higher blood flow rate per gram of tissue, such as the lungs, kidneys, brain, and liver, equilibrate more rapidly with arterial BAC than lower perfused ones, such as the skeletal muscles

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Therefore, exploring translatable biomarkers and combination strategies from epigenetic networks is the key to overcoming clinical dilemmas