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Description

Among the proteins identified, epiplakin 1 (EPPK1), GCN1 (activator of EIF2AK4), and CYP51A1 were found to be stabilized under heat shock conditions upon bortezomib treatment, indicating their targeting for proteasomal degradation under stress

As well to suggest more effective approaches therapy for DD patients

Repeated, method-validated measurements (scintigraphy or C-breath testing) in the same participants at treatment start and after weeks of steady state, for cagrilintide monotherapy, to test the tachyphylaxis hypothesis directly