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The most common initial symptom in this large series, observed in 68% of the patients when first seen, was the insidious onset of proximal leg stiffness followed by rigidity concurrently in the abdominal, lumbosacral and thoracic paraspinal muscles, lumbar hyperlordosis and impaired gait

Tetramer formation of tumor suppressor protein p53: Structure, function, and applications

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Nevertheless, their dose-dependent toxicity, particularly thrombocytopenia and neutropenia, represents a significant barrier to their widespread use [193]