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A meta-analysis of randomized, controlled trials demonstrated an approximately 2-fold increase in hospitalizations for heart failure among non-selective and COX-2 selective-treated patients compared to placebo (5)

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Borderline is 200300 pg/mL and low or deficient B12 is defined as 100 fL) means RBCs are larger than normal and can indicate anemia (Raposo LS, 2025)