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RRMM patients ( N = 304) who had received 1 prior therapy line (including lenalidomide and a PI) were randomized to receive daratumumab-Pd ( n = 151) or Pd alone ( n = 153)

High dose prednisolone was started with initial clinical and biochemical improvement

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This finding provides a mutational (contrary to the selective one) explanation for the observation that long-lived species have GC-rich mtDNA: long-lived species become GC-rich simply because of their biased process of mutagenesis

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