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and is the Senior Scientific Officer of Alimentiv Inc

While its role in anti-oxidation and inflammation is extensively studied, the additional roles of vitamin C in angiogenesis, extracellular matrix remodeling, and fibrosis are underscored for considering vitamin C as a therapeutic agent for cardiovascular diseases

In OA FLS, overexpression of HK2 increases RNA expression levels of pro-inflammatory cytokines such as IL-6 , IL-8 , and MMPs (49)

Kernicterus mechanism: When unconjugated bilirubin exceeds albumin-binding capacity (high bilirubin levels, low albumin, acidosis, or displacing drugs), free bilirubin crosses the BBB and deposits in the basal ganglia (globus pallidus, subthalamic nucleus), cerebellum, and hippocampus, causing oxidative damage and neuronal death

doi: 10.1093/eurpub/ckx143

Garcia-Manero G, Bose P, Alvarado Y, Borthakur G, Daver N, Ravandi F, Jabbour E, Takahashi K, Andreeff M , Kadia T, DiNardo C, Cortes J, Kornblau S, Naqvi K, Benton CB, Ohanian M, Konopleva M, Estrov Z, Montalban-Bravo G, Pierce S, Bodden K, Kantarjian H