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A study by Sarafian et al (1999) demonstrated significant dose-dependent increases in ROS production in vitro induced by marijuana cigarette smoke containing THC, which was manifested by higher nitrate levels measured in culture, compared with controls

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A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]

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Jul 2003;35 Suppl 3:S12-16

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