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Notably, EPAS1 (which encodes HIF-2) has shown a strong selection signal and is correlated with lower hemoglobin concentrations in Tibetans [2,3,4,5], whereas HIF1A (which encodes HIF-1) has not shown clear signs of selection among Tibetans [3]

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Therefore, a key question is whether certain individuals have an inflection point for clinically important paracetamol toxicity at a dose within or close to the recommended therapeutic dose