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For example, the copolymer (C-1 ) in the second coating may comprise methacrylic acid repeating units and methyl methacrylate repeating units in a molar ratio of 0.5:1 to 1.5:1 , preferably in a molar ratio of 0.8:1 to 1 :08, more preferably in a molar ratio of 1 :1

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Contraindications: Thiamine is contraindicated in patients with known sensitivity to Thiamineor any components of the preparation

But the science is still evolving