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283 In HCC, downregulation of the TGF- signaling pathway may imply loss of cancer suppressive activity, while upregulation leads to fibrosis and inflammation

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And in Japan, DKT has been integrated into the modern medical system as a prescription drug and is widely used for gastrointestinal diseases such as postoperative intestinal obstruction [324]

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However, in tumor cells, ROS-induced autophagy activation can promote cell development and cancer progression ( The Nrf2-dependent adaptive response, which includes phase II detoxifying enzymes, antioxidants, and transporters that protect cells from further carcinogenic assaults, is how chemopreventive substances or synthetic chemicals carry out their chemopreventive action