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doi: 10.1126/science.aan4665 146 Palsson-McDermottEMCurtisAMGoelGLauterbachMASheedyFJGleesonLEet al

By inhibiting microglial activation and the secretion of pro-inflammatory cytokines, AST helps preserve neuronal homeostasis

Meanwhile, the reduction in SCFA-producing and immunomodulatory taxa such as Lactobacillus implies a weakened gut barrier and a pro-inflammatory microbial profile conducive to endothelial dysfunction (Tang et al., 2019