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TNF- can directly breach the BBB, leading to microglia and astrocyte activation [57, 58]

Free radicals are highly reactive because they actively seek an electron to stabilize the molecule

10.1016/j.lfs.2019.117139 Pickart L, Margolina A

doi: 10.3390/jcm12031154 207 XiaZMengJWangXLiuPWuYXiongYet al

Glioma molecular subtypes and clinical manifestations are highly compatible with Piezo1 expression, as glioma is one of the most prevalent primary malignancies in the adult CNS (Kaushik and Persson, 2018