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Cagrilintide targets amylin receptors, producing satiety through a different neural pathway

J Clin Oncol 41:373384

PZ: Writing original draft, Writing review & editing

Nat Commun 13:

The gut mucosal response appears consistent across sex and hormonal status, making gut lining indications a strong match for female patients who are dealing with the GI consequences of hormonal fluctuation, antibiotic cycles, or inflammatory conditions

In adults with obesity or overweight and knee osteoarthritis, retatrutide at 12 mg produced 23.7% body weight loss (an average of 60 pounds) compared to 4.6% with placebo over a full treatment period