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Am J Physiol Cell Physiol 287(4):C817C833

Melasma, on the other hand, causes dark patches that most often appear on the face, usually on both sides

Effects of Drugs on Skin Conditions Cutaneous Drug Reactions (CDRs) occur when drugs cause changes in skin coloration ranging from yellowish discoloration and purple spots on light skinned people (called purpura) to black patches on dark-skinned individuals (called hyperpigmentation)