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SPNs were also recently investigated for the first time for detecting early synaptic transmission alterations exerted by -syn oligomers, combining multiple techniques like electrophysiology optogenetics, immunofluorescence, and molecular and behavioral analyses [106]

doi: 10.1016/j.redox.2022.102541 324 ThompsonJLakhaniN

27 MOLECULAR MECHANISMS OF STEROID RESISTANCE With more than a decade of studies attempting to identify the molecular mechanisms of steroid resistance, a lot of pathways and mechanisms have been explored

The rationale for such an approach is supported by studies such as Campbell C et al

Alisol a 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the ampk/mtor pathway

Mast cell activation generates reactive oxygen species and perpetuates oxidative damage