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How Serotonin Level Fluctuation Affects the Effectiveness of Treatment in Irritable Bowel Syndrome

Cochrane Database of Systematic Reviews

Pre-treatment with low micromolar doses (0.15 M) of ryanodine, which depletes SR Ca 2+ ( ex vivo arrhythmia incidence and cytosolic Ca 2+ accumulation induced by LCAC superfusion ( 45 Ca 2+ release is partially blocked by co-treatment with the ryanodine receptor inhibitor, ruthenium red ( 3 H]ryanodine binding within the SR membranes and markedly increase skeletal muscle ryanodine receptor (RyR1) open probability ( 3 H]ryanodine binding or the rapid 45 Ca 2+ release induced by LCAC treatment ( 2+ release in both skeletal and cardiac muscle