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Uddin MR S-Editor: Lin C L-Editor: A P-Editor: Wang CH Contributor Information Tanvi Sharma, Department of Biophysics, Panjab University, Chandigarh 160014, India

The GSSG/GSH redox couple plays a vital role in several enzymatic reactions, including the elimination of peroxides by GSH peroxidases (GPx), in covalent addition of cysteines to proteins by glutaredoxin , and in detoxification of electrophiles by GSH-S-transferase (GST) 585,586,587

Conversely, an unbalanced gut microbial population can prevent the activation of Th17 cells at the expense of Th1, Th2, and Treg cell differentiation

Lipopolysaccharide (LPS) released by Gram-negative bacteria activates TLR4 on Kupffer cells in the liver, promoting CXCL1 secretion and neutrophil recruitment (129, 130)