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doi: 10.1182/blood.2021010867 187 SongYZhuYHuBLiuYLinDJinZet al

Another important factor which can be attributed to the inability of seleno-GPxs to fully counter radiation toxicity is their restricted upregulation

We also studied the consequences of PA treatment on the expression of other well-known ferroptosis-related genes and found that PA induced a decreased expression of two key anti-ferroptotic genes: the gluthatione peroxidase 4 (GPX4) and the ferroptosis suppressor protein 1 (FSP1) and an enhanced expression of two key pro-ferroptotic genes: the arachidonate 15-lipoxygenase (ALOX15) and the acyl-CoA synthetase long chain family member 4 (ACSL4)