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Under oxidative stress, excessive Ca 2+ influx into mitochondria exacerbates mPTP activation and m loss ( 2+ dysregulation converge to drive mitochondrial collapse, ATP depletion, and skeletal myocyte apoptosis or necrosis-ultimately contributing to the pathogenesis of muscle atrophy ( 5.2.2 Mitochondrial dysfunction exacerbates ROS production: a vicious cycle Mitochondrial dysfunction both amplifies ROS generation and impairs antioxidant defense, establishing a self-perpetuating cycle of oxidative injury and organelle deterioration (Yazdani et al., 2023)

The Confidence Tiers We Use in This Review To keep this grounded, each item is labeled by evidence strength and real-world usefulness: Tier 1 (Strong): Consistent benefits across multiple studies and real-world use

Briefly, 5 ml 0.6% TBA in 10% trichloroacetic acid (TCA) was added in 1 g mortar and pestle grounded fresh vegetable amaranth leaf