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While compelling evidence establishes ferroptosis as a key driver of cyst progression in ADPKDlinked to PKD1/PKD2 mutations, disrupted antioxidant networks (GPX4/SLC7A11), iron overload, and lipid peroxidationand validates ferroptosis modulators as potential therapeutics, several critical, insufficiently addressed research gaps persist

(2021) 5(8):nzab037

Preserving muscle while losing fat is a major therapeutic goal in obesity medicine, as loss of muscle mass can worsen metabolic function and long-term outcomes

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Cureus 13 (11), e19325

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