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Developing next-generation selective STAT3 inhibitors targeting unique MDSC-specific pathways or combining upstream regulators (e.g., IL-6, JAK) with myeloid-restricted signals (e.g., S100A8/A9) can enhance specificity

Guo L, Qiu J, Li L-F, Lu B, Olsen K, Fan L

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These chemicals are degraded by gut microbial enzymes (choline-TMA lyases) into trimethylamine (TMA), which subsequently enters the portal circulation and is oxidized in the liver by flavin-containing monooxygenases (FMOs) to produce TMAO (158)

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Franklin CC, Backos DS, Mohar I, White CC, Forman HJ, Kavanagh TJ (2009) Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase