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The activation of the vtp gene when B

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TRPM2 is also activated by ADPR upon stimulation with other extracellular stimuli including TNF in mouse cardiac ventricular myocytes (Roberge et al., 2014), amyloid -peptide (A) in rat striatal cells (Fonfria et al., 2005), and Zn 2+ in mouse microglial cells (Mortadza et al., 2017)

When the Cu content in hepatocytes increases, ATP7B relocates to the bile duct membrane of the hepatocytes and excretes Cu from the biliary tract along with the bile through transmembrane transport

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