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Therefore, identifying direct markers of ferroptosissuch as oxidized phospholipids or GPX4 degradationis crucial for clinical diagnosis and therapeutic monitoring

This can be accomplished through the utilization of various pharmacological agents, such as DPP-4 inhibitors, SGLT2 inhibitors, insulin, glucagon-like peptide-1 (GLP-1) receptor agonists, and metformin (106)

Of note, NMNH has been recently declared self-affirmed GRAS, which should accelerate its clinical development

& Fatma, T

35,36 Several mechanisms may contribute to SARS-CoV-2-induced depletion and exhaustion of lymphocytes: (1) SARS-CoV-2 may directly infect T cells via ACE2 receptor expressed on T cells, 37 which results in T cell death

However, the large number of significant correlations noted in this study between Parasutterella relative abundance and EWAT metabolites strongly supports the relevance of this genus to the EWAT metabolome