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An LXR agonist promotes glioblastoma cell death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway

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2012;142(6):13601 SciClone.Zadaxin Product Monograph

Roberts BJ, Svoboda RA, Overmiller AM, Lewis JD, Kowalczyk AP, Mahoney MG

Among the other proteins recovered selectively in the Dmrta2 2XHA sample was the zinc-finger protein Zfp462 which regulates neural lineage specification by targeting the H3K9-specific histone methyltransferase complex G9A/GLP to silence meso-endodermal genes (Yelagandula et al., 2023) and the E3 ubiquitin ligases BRE1a and BRE1b that regulate the cell cycle and differentiation of neural precursor cells (NPCs) through monoubiquitylation of histone H2B (Ishino et al., 2014)

= Biomedecine Pharmacother