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Description

PMID: 23728197

d = dilution factor

PMID: 9685390 Rebouche CJ

Acta Neurochir Suppl 75 : 36 Persson L, Hillered L 1992 Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis

3.2 DNA methyltransferase inhibitors in clinical research 3.2.1 Dinucleotide derivant: Guadecitabine Guadecitabine (SGI-110, 5 ) is a dinucleotide derivative of decitabine, which inhibits DNA methylation by the same mechanism of decitabine, but its PK and stability are superior to those of decitabine due to the phosphodiester bond of SGI-110, which can resist the transient degradation of cytidine deaminase