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Likewise, the overexpression of adhesion molecules like ICAM-4 and CD36 is associated with the severity of vascular problems in sickle cell aneamia and malaria, and their monitoring may offer clinicians important metrics for evaluating disease progression and treatment effectiveness

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Aetiology is unclear, but it is thought that the antibodies may block TSH receptors and that this results in the hypothyroidism

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These studies were conducted in both the United States (94 patients) and the European Union (74 patients) using similar methodology