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Brandl C, Bucci L, Schett G, Zaiss MM

G.FerrieA.et al (2004)

However, functional downregulation and/or desensitization of MOR has also been observed in the spinal dorsal horn, particularly in laminae I and II, in nerve-injury neuropathy [101,130] and diabetic neuropathy [131,132], although with no significant decrease in expression [78,130,131,132]

Nrf2, Nuclear factor erythroid 2-related factor 2

We found that intracellular 1-MNA and NNMT protein expression levels were substantially higher in the fully differentiated adipocytes compared to the undifferentiated pre-adipocytes, which is consistent with the differentiation-dependent enhancement in NNMT mRNA levels and enzymatic activity reported previously in the 3T3-L1 cell lines.[37] The higher levels of 1-MNA and NNMT in adipocytes compared to pre-adipocytes may partially account for our observations that increasing concentrations (10 60 M) of NNMT inhibitor did not completely eliminate 1-MNA in adipocytes, but did fully suppress 1-MNA accumulation in undifferentiated pre-adipocytes

Non-rodent animal models for IVD include rabbits, which display a similar disc morphology to humans and have been used to study degeneration as well as potential therapeutics (Kroeber et al., 2002